Low Progesterone and Low Estradiol Levels Associate With Abdominal Aortic Aneurysms in Men.

ABSTRACT:

Context

Male sex is a major risk factor for abdominal aortic aneurysms (AAA) but few studies have addressed associations between sex hormone levels and AAA.

Objective

We aimed to describe the associations between serum sex steroids and early, screening-detected AAA in men.

Methods

We validated a high-sensitivity liquid chromatography-tandem mass spectrometry assay for comprehensive serum sex hormone profiling. This assay was then employed in a case-control study including 147 men with AAA (infrarenal aorta ≥ 30 mm) and 251 AAA-free controls recruited at the general population-based ultrasound screening for AAA in 65-year-old Swedish men.

Outcomes included

associations between dehydroepiandrosterone, progesterone, 17α-hydroxyprogesterone, androstenedione, estron

SUBMITTER: Ohlsson C 

PROVIDER: S-EPMC8947245 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature