Clinical Impact of High Throughput Sequencing on Liquid Biopsy in Advanced Solid Cancer.

ABSTRACT:

Background

Cancer therapies targeting actionable molecular alterations (AMA) have developed, but the clinical routine impact of high-throughput molecular profiling remains unclear. We present a monocentric experience of molecular profiling based on liquid biopsy in patients with cancer.

Methods

Patients included had solid cancer and underwent cfDNA genomic profiling with FoudationOne Liquid CDx (F1LCDx) test, analyzing 324 genes. Primary endpoint was to describe patients with an AMA for whom clinical decisions were impacted by F1LCDx test results.

Results

191 patients were included, mostly with lung cancer (46%). An AMA was found in 52%. The most common molecular alterations were: TP53 (52%), KRAS (14%) and DNMT3 (11%). The most common AMA were: CHEK2 (10%), PIK3CA (9

SUBMITTER: Gouton E 

PROVIDER: S-EPMC8947301 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature