Pathological and Genetic Stratification for Management of Adrenocortical Carcinoma.

ABSTRACT:

Context

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy that affects patients across the age spectrum. Although the overall survival in patients with ACC is poor, there is significant heterogeneity in terms of outcomes, presentation, and underlying genetic drivers.

Evidence acquisition

This review is based on the evidence collected from primary research studies, expert reviews, and published guidelines. The studies were identified through PubMed search with key words "adrenocortical carcinoma," "prognosis," "pathology," and "genetics." The PubMed search was complemented by authors' expertise, research, and clinical experience in the field of ACC.

Evidence synthesis

Identification of biomarkers has been critical to gain better insight into tumor behavior

SUBMITTER: Clay MR 

PROVIDER: S-EPMC8947319 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature