Ciliated (FOXJ1⁺) Cells Display Reduced Ferritin Light Chain in the Airways of Idiopathic Pulmonary Fibrosis Patients.

ABSTRACT: Cell-based therapies hold great promise in re-establishing organ function for many diseases, including untreatable lung diseases such as idiopathic pulmonary fibrosis (IPF). However, many hurdles still remain, in part due to our lack of knowledge about the disease-driving mechanisms that may affect the cellular niche and thereby possibly hinder the function of any transplanted cells by imposing the disease phenotype onto the newly generated progeny. Recent findings have demonstrated increased ciliation of lung cells from IPF patients, but how this affects ciliated cell function and the airway milieu is not well-known. Here, we performed single-cell RNA sequencing on primary ciliated (FOXJ1⁺) cells isolated from IPF patients and from healthy control donors. The sequencing identif

SUBMITTER: Wijk SC 

PROVIDER: S-EPMC8947470 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature