VEGFA Haplotype and VEGF-A and VEGF-R2 Protein Associations with Exudative Age-Related Macular Degeneration.

ABSTRACT: Our study aimed to reveal the associations between VEGFA SNPs (rs1570360, rs699947, rs3025033, and rs2146323), their haplotypes, VEGF-A and VEGF-R2 serum concentrations, and early and exudative AMD. A total of 339 subjects with early AMD and 419 with exudative AMD groups, and 374 healthy subjects, were genotyped for four VEGFA SNPs (rs1570360, rs699947, rs3025033, and rs2146323). VEGF-A and VEGFR-2 serum concentrations were measured in exudative AMD and controls. The results revealed that rs3025033 G allele was significantly associated with lower odds of exudative AMD under the dominant model (OR = 0.67; 95% CI: 0.49-0.80; p = 0.0088) and additive (OR = 0.7; 95% CI: 0.54-0.90; p = 0.0058) models after Bonferroni correction. In the female group, rs3025033 AG geno

SUBMITTER: Vilkeviciute A 

PROVIDER: S-EPMC8947491 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature