Endogenous Leptin Concentrations Poorly Predict Metreleptin Response in Patients With Partial Lipodystrophy.

ABSTRACT:

Context

Leptin replacement with metreleptin improves glycemia and hypertriglyceridemia in severely hypoleptinemic patients with generalized lipodystrophy (GLD), but its effects are variable in partially leptin-deficient patients with partial lipodystrophy (PLD).

Objective

Compare 3 leptin assays (Study I); identify diagnostic performance of leptin assays to detect responders to metreleptin for each assay (Study II).

Design

Study I: cross-sectional analysis of average bias between leptin assays. Study II: retrospective analysis of diagnostic accuracy of potential leptin cut points to detect clinical responders to metreleptin.

Setting

National Institutes of Health; University of Michigan.

Participants and interventions

Study I: Metreleptin-naïve patients w

SUBMITTER: Meral R 

PROVIDER: S-EPMC8947785 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature