A functional genomics approach in Tanzanian population identifies distinct genetic regulators of cytokine production compared to European population.

ABSTRACT: Humans exhibit remarkable interindividual and interpopulation immune response variability upon microbial challenges. Cytokines play a vital role in regulating inflammation and immune responses, but dysregulation of cytokine responses has been implicated in different disease states. Host genetic factors were previously shown to significantly impact cytokine response heterogeneity mainly in European-based studies, but it is unclear whether these findings are transferable to non-European individuals. Here, we aimed to identify genetic variants modulating cytokine responses in healthy adults of East African ancestry from Tanzania. We leveraged both cytokine and genetic data and performed genome-wide cytokine quantitative trait loci (cQTLs) mapping. The results were compared with another cohort

SUBMITTER: Boahen CK 

PROVIDER: S-EPMC8948159 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature