The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties.

ABSTRACT:

Background

Osteosarcoma (OS) is the most common type of primary bone cancer affecting children and adolescents. OS has a high propensity to spread meaning the disease is often incurable and fatal. There have been no improvements in survival rates for decades. This highlights an urgent need for the development of novel therapeutic strategies. Here, we report in vitro and in vivo data that demonstrates the role of purinergic signalling, specifically, the B isoform of the purinergic receptor P2RX7 (P2RX7B), in OS progression and metastasis.

Methods

TE85 and MNNG-HOS OS cells were transfected with P2RX7B. These cell lines were then characterised and assessed for proliferation, cell adhesion, migration and invasion in vitro. We used these cells to perform bot

SUBMITTER: Tattersall L 

PROVIDER: S-EPMC8948168 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature