Biomolecular engineering of drugs loading in Riboflavin-targeted polymeric devices: simulation and experimental.

ABSTRACT: The synthesis of polymeric nanoparticles (NPs) with efficient drug loading content and targeting moieties is an attractive field and remains a challenge in drug delivery systems. Atomistic investigations can provide an in-depth understanding of delivery devices and reduce the number of expensive experiments. In this paper, we studied the self-assembly of poly (lactic-co-glycolic acid)-b-poly (ethylene glycol) with different molecular weights and surface compositions. The innovation of this molecular study is the loading of an antitumor drug (docetaxel) on a targeting ligand (riboflavin). According to this work, a novel, biocompatible and targeted system for cancer treatment has been developed. The obtained results revealed a correlation between polymer molecular weight and the stability of

SUBMITTER: Khedri M 

PROVIDER: S-EPMC8948184 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature