Metabolic benefits of methionine restriction in adult mice do not require functional methionine sulfoxide reductase A (MsrA).

ABSTRACT: Methionine restriction (MR) extends lifespan and improves several markers of health in rodents. However, the proximate mechanisms of MR on these physiological benefits have not been fully elucidated. The essential amino acid methionine plays numerous biological roles and limiting its availability in the diet directly modulates methionine metabolism. There is growing evidence that redox regulation of methionine has regulatory control on some aspects of cellular function but interactions with MR remain largely unexplored. We tested the functional role of the ubiquitously expressed methionine repair enzyme methionine sulfoxide reductase A (MsrA) on the metabolic benefits of MR in mice. MsrA catalytically reduces both free and protein-bound oxidized methionine, thus playing a key role in its r

SUBMITTER: Thyne KM 

PROVIDER: S-EPMC8948287 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature