Intratumoral in vivo staging of breast cancer by multi-tracer PET and advanced analysis.

ABSTRACT: The staging and local management of breast cancer involves the evaluation of the extent and completeness of excision of both the invasive carcinoma component and also the intraductal component or ductal carcinoma in situ. When both invasive ductal carcinoma and coincident ductal carcinoma in situ are present, assessment of the extent and localization of both components is required for optimal therapeutic planning. We have used a mouse model of breast cancer to evaluate the feasibility of applying molecular imaging to assess the local status of cancers in vivo. Multi-tracer positron emission tomography (PET) and magnetic resonance imaging (MRI) characterize the transition from premalignancy to invasive carcinoma. PET tracers for glucose consumption, membrane synthesis, and neoangiogenesis i

SUBMITTER: Griessinger J 

PROVIDER: S-EPMC8948294 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature