Association between maternal adversity, DNA methylation, and cardiovascular health of offspring: a longitudinal analysis of the ALSPAC cohort study.

ABSTRACT:

Objectives

Maternal adversity during pregnancy has been shown to be associated with some health outcomes in the offspring. This study investigated the association of maternal adversity during pregnancy and DNA methylation with offspring cardiovascular (CV) health.

Design

Longitudinal observational cohort study SETTING: All pregnant residents in county Avon (∼0.9 million), UK, were eligible to participate if their estimated delivery date was between 1 April 1991 and 31 December 1992.

Participants

Mother-offspring pairs enrolled in the Avon Longitudinal Study of Parents and Children cohort at seven (n=7431) and 17 years of age (n=3143).

Primary and secondary outcome measures

Offspring CV health primary measures were heart rate (HR), blood pressure (BP) and second

SUBMITTER: Hyde NK 

PROVIDER: S-EPMC8948393 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature