Coeliac plexus radiosurgery for pain management in patients with advanced cancer : study protocol for a phase II clinical trial.

ABSTRACT:

Introduction

Pancreatic cancer is characterised by severe mid-back and epigastric pain caused by tumour invasion of the coeliac nerve plexus. This pain is often poorly managed with standard treatments. This clinical trial investigates a novel approach in which high-dose radiation (radiosurgery) is targeted to the retroperitoneal coeliac plexus nerve bundle. Preliminary results from a single institution pilot trial are promising: pain relief is substantial and side effects minimal. The goals of this study are to validate these findings in an international multisetting, and investigate the impact on quality of life and functional status among patients with terminal cancer.

Methods and analysis

A single-arm prospective phase II clinical trial. Eligible patients are required to

SUBMITTER: Jacobson G 

PROVIDER: S-EPMC8948399 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature