Sex differences in the risk of recurrent ischemic stroke after ischemic stroke and transient ischemic attack.

ABSTRACT:

Background

Sex differences in stroke outcomes have been noted, but whether this extends to stroke recurrence is unclear. We examined sex differences in recurrent stroke using data from the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) trial.

Patients and methods

We assessed the risk of recurrent stroke in women compared to men using data from the POINT trial. Adults >18 years old were randomized within 12 hours of onset of minor ischemic stroke or transient ischemic attack (TIA), and followed for up to 90 days for ischemic stroke, our primary outcome. We used Cox proportional hazards model adjusted for demographics and stroke risk factors to evaluate the association between sex and stroke recurrence. We used interaction term testing and prespecifi

SUBMITTER: Basu E 

PROVIDER: S-EPMC8948518 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature