Proteasomal Processing Immune Escape Mechanisms in Platinum-Treated Advanced Bladder Cancer.

ABSTRACT: In recent years, the number and type of treatment options in advanced bladder cancer (BC) have been rapidly evolving. To select an effective therapy and spare unnecessary side effects, predictive biomarkers are urgently needed. As the host's anti-cancer immune response is by far the most effective system to impede malignant tumor growth, immune system-based biomarkers are promising. We have recently described altered proteasomal epitope processing as an effective immune escape mechanism to impair cytotoxic T-cell activity. By altering the neoantigens' characteristics through different proteasomal peptide cleavage induced by non-synonymous somatic mutations, the ability for T-cell activation was decreased ("processing escapes"). In the present study, we analyzed primary chemo-naïve tissue s

SUBMITTER: Wessolly M 

PROVIDER: S-EPMC8948673 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature