Dihydropyridines Potentiate ATP-Induced Currents Mediated by the Full-Length Human P2X5 Receptor.

ABSTRACT: The P2X5 receptor, an ATP-gated cation channel, is believed to be involved in tumor development, inflammatory bone loss and inflammasome activation after bacterial infection. Therefore, it is a worthwhile pharmacological target to treat the corresponding diseases, especially in minority populations that have a gene variant coding for functional homotrimeric P2X5 channels. Here, we investigated the effects of dihydropyridines on the human full-length P2X5 receptor (hP2X5^FL) heterologously expressed in Xenopus oocytes using the two-microelectrode voltage clamp method. Agonist dependency, kinetics and permeation behavior, including Cl^- permeability, were similar to hP2X5^FL expressed in HEK293 or 1321N1 cells. Additionally, 1,4-dihydropyridines have been

SUBMITTER: Schiller IC 

PROVIDER: S-EPMC8948676 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature