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Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202.

ABSTRACT: Two undescribed cytochalasins, emeriglobosins A (1) and B (2), together with nine previously reported analogues (3-11) and two known tetramic acid derivatives (12, 13) were isolated from the solid culture of Emericellopsis sp. SCSIO41202. Their structures, including the absolute configurations of their stereogenic carbons, were fully elucidated based on spectroscopic analysis and the calculated ECD. Some of the isolated compounds were evaluated for their cytotoxicity and enzyme inhibitory activity against acetylcholinesterase (AChE) in vitro. Among them, 8 showed potent AChE inhibitory activity, with an IC50 value of 1.31 μM, and 5 showed significant cytotoxicity against PC-3 cells, with an IC50 value of 2.32 μM.

SUBMITTER: Shao S

PROVIDER: S-EPMC8948984 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202.

Shao Surun S Wang Xueni X She Jianglian J Zhang Han H Pang Xiaoyan X Lin Xiuping X Zhou Xuefeng X Liu Yonghong Y Li Yunqiu Y Yang Bin B

Molecules (Basel, Switzerland) 20220311 6

Two undescribed cytochalasins, emeriglobosins A (1) and B (2), together with nine previously reported analogues (3-11) and two known tetramic acid derivatives (12, 13) were isolated from the solid culture of Emericellopsis sp. SCSIO41202. Their structures, including the absolute configurations of their stereogenic carbons, were fully elucidated based on spectroscopic analysis and the calculated ECD. Some of the isolated compounds were evaluated fo ...[more]

PMID: 35335187

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