Dataset Information

Amperometric Monitoring of Dissolution of pH-Responsive EUDRAGIT® Polymer Film Coatings.

ABSTRACT: Electrochemical sensors are powerful tools for the detection and real-time monitoring of a wide variety of analytes. However, the long-term operation of Faradaic sensors in complex media is challenging due to fouling. The protection of the electrode surface during in vivo operation is a key element for improving the monitoring of analytes. Here, we study different EUDRAGIT® controlled release acrylate copolymers for protecting electrode surfaces. The dissolution of these polymers-namely EUDRAGIT® L 30 D-55 and EUDRAGIT® FS 30 D-is triggered by a change in pH of the environment, and it is electrochemically monitored by detecting electrode access by means of a redox probe. The full dissolution of the polymer is achieved within 30 min and the electrode response indicates a complete recovery of the original electrochemical performance. We demonstrate that amperometric sensing is a practical and straightforward technique for real-time and in situ sensing of EUDRAGIT® dissolution profiles. It will find future applications in determining the protection of polymer electrode coating in real matrices and in vivo applications.

SUBMITTER: Mestres J

PROVIDER: S-EPMC8949041 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Amperometric Monitoring of Dissolution of pH-Responsive EUDRAGIT<sup>®</sup> Polymer Film Coatings.

Mestres Júlia J Leonardi Francesca F Mathwig Klaus K

Micromachines 20220225 3

Electrochemical sensors are powerful tools for the detection and real-time monitoring of a wide variety of analytes. However, the long-term operation of Faradaic sensors in complex media is challenging due to fouling. The protection of the electrode surface during in vivo operation is a key element for improving the monitoring of analytes. Here, we study different EUDRAGIT<sup>®</sup> controlled release acrylate copolymers for protecting electrode surfaces. The dissolution of these polymers-name ...[more]

PMID: 35334654

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Project description:Functional and stimuli-responsive nanofibers with an enhanced surface area/volume ratio provide controlled and triggered drug release with higher efficacy. In this study, chemotherapeutic agent Rose Bengal (RB) (4,5,6,7-tetrachloro-2', 4',5',7'-tetraiodofluoresceindisodium)-loaded water-soluble polyvinyl alcohol (PVA) nanofibers were synthesized by using the electrospinning method. A thin layer of poly(4-vinylpyridine-co-ethylene glycol dimethacrylate) p(4VP-co-EGDMA) was deposited on the RB-loaded nanofibers (PVA-RB) via initiated chemical vapor deposition (iCVD), coating the fiber surfaces to provide controllable solubility and pH response to the nanofibers. The uncoated and [p(4VP-co-EGDMA)-PVA] coated PVA-RB nanofiber mats were studied at different pH values to analyze their degradation and drug release profiles. The coated nanofibers demonstrated high stability at neutral and basic pH values for long incubation durations of 72 h, whereas the uncoated nanofibers dissolved in <2 h. The drug release studies showed that the RB release from coated PVA-RB nanofibers was higher at neutral and basic pH values, and proportional to the pH of the solution, whereas the degradation and RB release rates from the uncoated PVA-RB nanofibers were significantly higher and did not depend on the pH of environment. Further analysis of the release kinetics using the Peppas model showed that while polymer swelling and dissolution were the dominant mechanisms for the uncoated nanofibers, for the coated nanofibers, Fickian diffusion was the dominant release mechanism. The biocompatibility and therapeutic efficiency of the coated PVA-RB nanofibers against brain cancer was investigated on glioblastoma multiforme cancer cells (U87MG). The coated PVA nanofibers were observed to be highly biocompatible, and they significantly stimulated the ROS production in cells, increasing apoptosis. These promising results confirmed the therapeutic activity of the coated PVA-RB nanofibers on brain cancer cells, and encouraged their further evaluation as drug carrier structures in brain cancer treatment.

Dataset Information

Amperometric Monitoring of Dissolution of pH-Responsive EUDRAGIT® Polymer Film Coatings.

Publications

Amperometric Monitoring of Dissolution of pH-Responsive EUDRAGIT<sup>®</sup> Polymer Film Coatings.

Similar Datasets

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