New Synthetic Analogues of Natural Polyphenols as Sirtuin 1-Activating Compounds.

ABSTRACT: NAD⁺-dependent deacetylase SIRT1 regulates many different biological processes, thus being involved in pathogenic conditions such as metabolic diseases, neurogenerative disorders and cancer. Notably, experimental evidence underlined that the activation of SIRT1 had promising cardioprotective effects. Consequently, many efforts have been so far devoted to finding new SIRT1 activators, both derived from natural sources or prepared by synthetic procedures. Herein, we discovered new SIRT1-activating derivatives, characterized by phenolic rings spaced by sulfur, nitrogen or oxygen-based central linkers. The newly synthesized derivatives were analyzed in enzymatic assays to determine their ability to activate SIRT1, as compared with that of resveratrol. Among the tested molecules, bis

SUBMITTER: Bononi G 

PROVIDER: S-EPMC8949162 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature