The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response.

ABSTRACT: Lysine-specific methyltransferase 7 (KMT7) SET7/9, aka Set7, Set9, or SetD7, or KMT5 was discovered 20 years ago, yet its biological role remains rather enigmatic. In this review, we analyze the particularities of SET7/9 enzymatic activity and substrate specificity with respect to its biological importance, mostly focusing on its two well-characterized biological functions: cellular proliferation and stress response.

SUBMITTER: Daks A 

PROVIDER: S-EPMC8949485 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature