Inflammation and neutrophil extracellular traps in cerebral cavernous malformation.

ABSTRACT: Cerebral Cavernous Malformation (CCM) is a brain vascular disease with various neurological symptoms. In this study, we describe the inflammatory profile in CCM and show for the first time the formation of neutrophil extracellular traps (NETs) in rodents and humans with CCM. Through RNA-seq analysis of cerebellum endothelial cells from wild-type mice and mice with an endothelial cell-specific ablation of the Ccm3 gene (Ccm3^iECKO), we show that endothelial cells from Ccm3^iECKO mice have an increased expression of inflammation-related genes. These genes encode proinflammatory cytokines and chemokines, as well as adhesion molecules, which promote recruitment of inflammatory and immune cells. Similarly, immunoassays showed elevated levels of these cytokines and chemokines

SUBMITTER: Yau ACY 

PROVIDER: S-EPMC8949649 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature