Transendocardial CD34⁺ Cell Therapy Improves Local Mechanical Dyssynchrony in Patients With Nonischemic Dilated Cardiomyopathy.

ABSTRACT: We investigated the effects of cell therapy on local mechanical dyssynchrony (LMD) in patients with nonischemic dilated cardiomyopathy (NICM). We analyzed electromechanical data of 30 NICM patients undergoing CD34⁺ cell transplantation. All patients underwent bone marrow stimulation; CD34⁺ cells were collected by apheresis and injected transendocardially. At baseline and at 6 months after therapy, we performed electromechanical mapping and measured unipolar voltage (UV) and LMD at cell injection sites. LMD was defined as a temporal difference between global and segmental peak systolic displacement normalized to the average duration of the RR interval. Favorable clinical response was defined as increase in the left ventricular ejection fraction (LVEF) ≥5% between basel

SUBMITTER: Zorz N 

PROVIDER: S-EPMC8949703 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature