Blood-brain barrier dysfunction and reduced cerebrospinal fluid levels of soluble amyloid precursor protein-β in patients with subcortical small-vessel disease.

ABSTRACT:

Introduction

Subcortical small-vessel disease (SSVD) is the most common vascular cognitive disorder. However, because no disease-specific cerebrospinal fluid (CSF) biomarkers are available for SSVD, our aim was to identify such markers.

Methods

We included 170 healthy controls and patients from the Gothenburg Mild Cognitive Impairment (MCI) study clinically diagnosed with SSVD dementia, Alzheimer's disease (AD), or mixed AD/SSVD. We quantified CSF levels of amyloid-β (Aβ)_x-38, Aβ_x-40, Aβ_x-42, as well as soluble amyloid precursor protein (sAPP)-α and sAPP-β.

Results

sAPP-β was lower in SSVD patients than in AD patients and controls. Receiver-operating characteristic (ROC) analyses showed that sAPP-β moderately separated SSVD from AD and

SUBMITTER: Kettunen P 

PROVIDER: S-EPMC8949877 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature