Cytolytic Properties and Genome Analysis of Rigvir^® Oncolytic Virotherapy Virus and Other Echovirus 7 Isolates.

ABSTRACT: Rigvir^® is a cell-adapted, oncolytic virotherapy enterovirus, which derives from an echovirus 7 (E7) isolate. While it is claimed that Rigvir^® causes cytolytic infection in several cancer cell lines, there is little molecular evidence for its oncolytic and oncotropic potential. Previously, we genome-sequenced Rigvir^® and five echovirus 7 isolates, and those sequences are further analyzed in this paper. A phylogenetic analysis of the full-length data suggested that Rigvir^® was most distant from the other E7 isolates used in this study, placing Rigvir^® in its own clade at the root of the phylogeny. Rigvir^® contained nine unique mutations in the viral capsid proteins VP1-VP4 across the whole data set, with a structural analysis

SUBMITTER: Hietanen E 

PROVIDER: S-EPMC8949920 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature