Prenatal Exposure to Traffic-Related Air Pollution and the DNA Methylation in Cord Blood Cells: MOCEH Study.

ABSTRACT: Particulate matter with a diameter of ≤10 µm (PM₁₀) and nitrogen dioxide (NO₂) affect the DNA methylation in the fetus, but epigenetic studies regarding prenatal exposure to air pollution in Asia are lacking. Therefore, this study aimed to assess whether there is any association between the ambient concentrations of PM₁₀ and NO₂ and CpG methylation in the cord blood DNA by using a Korean birth cohort. The concentrations of the air pollutants were incorporated into the final LUR model by using the maternal address data. The methylation level was determined using HumanMethylationEPIC BeadChip and a linear regression analysis model. A multipollutant model including both PM₁₀ and NO₂ and models with single pollutants were used f

SUBMITTER: Park J 

PROVIDER: S-EPMC8949945 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature