Clinical Evidence of Cannabinoids in Migraine: A Narrative Review.
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ABSTRACT:
SUBMITTER: Lo Castro F
PROVIDER: S-EPMC8949974 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Publications
Clinical Evidence of Cannabinoids in Migraine: A Narrative Review.
Lo Castro Flavia F Baraldi Carlo C Pellesi Lanfranco L Guerzoni Simona S
Journal of clinical medicine 20220308 6
The endocannabinoid system (ECS) influences many biological functions, and hence, its pharmacological modulation may be useful for several disorders, such as migraine. Preclinical studies have demonstrated that the ECS is involved in the modulation of trigeminal excitability. Additionally, clinical data have suggested that an endocannabinoid deficiency is associated with migraine. Given these data, phytocannabinoids, as well as synthetic cannabinoids, have been tried as migraine treatments. In t ...[more]
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