Etiologic Classification of Diffuse Parenchymal (Interstitial) Lung Diseases.

ABSTRACT: Interstitial lung diseases (ILD) or diffuse parenchymal lung diseases (DPLD) comprise a large number of disorders. Disease definition and classification allow advanced and personalized judgements on clinical disease, risks for genetic or environmental transmissions, and precision medicine treatments. Registers collect specific rare entities and use ontologies for a precise description of complex phenotypes. Here we present a brief history of ILD classification systems from adult and pediatric pneumology. We center on an etiologic classification, with four main categories: lung-only (native parenchymal) disorders, systemic disease-related disorders, exposure-related disorders, and vascular disorders. Splitting diseases into molecularly defined entities is key for precision medicine and the

SUBMITTER: Griese M 

PROVIDER: S-EPMC8950114 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature