Calcium selective channel TRPV6: Structure, function, and implications in health and disease.

ABSTRACT: Calcium-selective channel TRPV6 (Transient Receptor Potential channel family, Vanilloid subfamily member 6) belongs to the TRP family of cation channels and plays critical roles in transcellular calcium (Ca²⁺) transport, reuptake of Ca²⁺ into cells, and maintaining a local low Ca²⁺ environment for certain biological processes. Recent crystal and cryo-electron microscopy-based structures of TRPV6 have revealed mechanistic insights on how the protein achieves Ca²⁺ selectivity, permeation, and inactivation by calmodulin. The TRPV6 protein is expressed in a range of epithelial tissues such as the intestine, kidney, placenta, epididymis, and exocrine glands such as the pancreas, prostate and salivary, sweat, and mammary glands. The TRPV6 gene is a dir

SUBMITTER: Khattar V 

PROVIDER: S-EPMC8950124 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature