Structure of a B₁₂-dependent radical SAM enzyme in carbapenem biosynthesis.

ABSTRACT: Carbapenems are antibiotics of last resort in the clinic. Owing to their potency and broad-spectrum activity, they are an important part of the antibiotic arsenal. The vital role of carbapenems is exemplified by the approval acquired by Merck from the US Food and Drug Administration (FDA) for the use of an imipenem combination therapy to treat the increased levels of hospital-acquired and ventilator-associated bacterial pneumonia that have occurred during the COVID-19 pandemic¹. The C6 hydroxyethyl side chain distinguishes the clinically used carbapenems from the other classes of β-lactam antibiotics and is responsible for their low susceptibility to inactivation by occluding water from the β-lactamase active site². The construction of the C6 hydroxyethyl side chain i

SUBMITTER: Knox HL 

PROVIDER: S-EPMC8950224 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature