IMGT^® Biocuration and Analysis of the Rhesus Monkey IG Loci.

ABSTRACT: The adaptive immune system, along with the innate immune system, are the two main biological processes that protect an organism from pathogens. The adaptive immune system is characterized by the specificity and extreme diversity of its antigen receptors. These antigen receptors are the immunoglobulins (IG) or antibodies of the B cells and the T cell receptors (TR) of the T cells. The IG are proteins that have a dual role in immunity: they recognize antigens and trigger elimination mechanisms, to rid the body of foreign cells. The synthesis of the immunoglobulin heavy and light chains requires gene rearrangements at the DNA level in the IGH, IGK, and IGL loci. The rhesus monkey (Macaca mulatta) is one of the most widely used nonhuman primate species in biomedical research. In this ma

SUBMITTER: Nguefack Ngoune V 

PROVIDER: S-EPMC8950363 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature