Melatonin Signaling Pathways Implicated in Metabolic Processes in Human Granulosa Cells (KGN).

ABSTRACT: Female reproduction depends on the metabolic status, especially during the period of folliculogenesis. Even though it is believed that melatonin can improve oocyte competence, there is still limited knowledge of how it can modulate metabolic processes during folliculogenesis and which signaling pathways are involved in regulating gene expression. To investigate the effects of melatonin on metabolic signals during the antral stage of follicular development, human granulosa-like tumor cells (KGN) were treated with melatonin or forskolin, and gene expression was analyzed with RNA-seq technology. Following appropriate normalization and the application of a fold change cut-off of 1.5 (FC 1.5, p ≤ 0.05), 1009 and 922 genes were identified as differentially expressed in response to melatonin and

SUBMITTER: Asma A 

PROVIDER: S-EPMC8950389 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature