Global Transcriptomic Response of Staphylococcus aureus to Virulent Bacteriophage Infection.

ABSTRACT: In light of the ever-increasing number of multidrug-resistant bacteria worldwide, bacteriophages are becoming a valid alternative to antibiotics; therefore, their interactions with host bacteria must be thoroughly investigated. Here, we report genome-wide transcriptional changes in a clinical Staphylococcus aureus SA515 strain for three time points after infection with the vB_SauM-515A1 kayvirus. Using an RNA sequencing approach, we identify 263 genes that were differentially expressed (DEGs) between phage-infected and uninfected host samples. Most of the DEGs were identified at an early stage of phage infection and were mainly involved in nucleotide and amino acid metabolism, as well as in cell death prevention. At the subsequent infection stages, the vast majority of DEGs were upr

SUBMITTER: Kuptsov N 

PROVIDER: S-EPMC8950790 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature