Prevention of Herpesviridae Infections by Cationic PEGylated Carbosilane Dendrimers.

ABSTRACT: Infections caused by viruses from the Herpesviridae family produce some of the most prevalent transmitted diseases in the world, constituting a serious global public health issue. Some of the virus properties such as latency and the appearance of resistance to antiviral treatments complicate the development of effective therapies capable of facing the infection. In this context, dendrimers present themselves as promising alternatives to current treatments. In this study, we propose the use of PEGylated cationic carbosilane dendrimers as inhibitors of herpes simplex virus 2 (HSV-2) and human cytomegalovirus (HCMV)infections. Studies of mitochondrial toxicity, membrane integrity, internalization and viral infection inhibition indicated that G2-SN15-PEG, G3-SN31-PEG, G2-SN15-PEG fluorescein i

SUBMITTER: Royo-Rubio E 

PROVIDER: S-EPMC8950866 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature