Comparative Venomics of C. flavidus and C. frigidus and Closely Related Vermivorous Cone Snails.

ABSTRACT: Cone snail venom biodiversity reflects dietary preference and predatory and defensive envenomation strategies across the ≈900 species of Conidae. To better understand the mechanisms of adaptive radiations in closely related species, we investigated the venom of two phylogenetically and spatially related species, C. flavidus and C. frigidus of the Virgiconus clade. Transcriptomic analysis revealed that the major superfamily profiles were conserved between the two species, including 68 shared conotoxin transcripts. These shared transcripts contributed 90% of the conotoxin expression in C. frigidus and only 49% in C. flavidus, which showed greater toxin diversification in the dominant O1, I2, A, O2, O3, and M superfamilies compared to C. frigidus</

SUBMITTER: Himaya SWA 

PROVIDER: S-EPMC8951504 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature