Differential Peripheral Blood Glycoprotein Profiles in Symptomatic and Asymptomatic COVID-19.

ABSTRACT: Glycosylation is the most common form of post-translational modification of proteins, critically affecting their structure and function. Using liquid chromatography and mass spectrometry for high-resolution site-specific quantification of glycopeptides coupled with high-throughput artificial intelligence-powered data processing, we analyzed differential protein glycoisoform distributions of 597 abundant serum glycopeptides and nonglycosylated peptides in 50 individuals who had been seriously ill with COVID-19 and in 22 individuals who had recovered after an asymptomatic course of COVID-19. As additional comparison reference phenotypes, we included 12 individuals with a history of infection with a common cold coronavirus, 16 patients with bacterial sepsis, and 15 healthy subjects without hi

SUBMITTER: Pickering C 

PROVIDER: S-EPMC8951729 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature