Alteration of Serum Proteome in Levo-Thyroxine-Euthyroid Thyroidectomized Patients.

ABSTRACT: The monotherapy with levo-thyroxine (LT4) is the treatment of choice for patients with hypothyroidism after thyroidectomy. However, many athyreotic LT4-treated patients with thyroid hormones in the physiological range experience hypothyroid-like symptoms, showing post-operative, statistically significant lower FT3 levels with respect to that before total thyroidectomy. Since we hypothesized that the lower plasmatic FT3 levels observed in this subgroup could be associated with tissue hypothyroidism, here we compared, by a preliminary proteomic analysis, eight sera of patients with reduced post-surgical FT3 to eight sera from patients with FT3 levels similar to pre-surgery levels, and six healthy controls. Proteomic analysis highlights a different serum protein profile among the considered c

SUBMITTER: Landi C 

PROVIDER: S-EPMC8951767 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature