Meta-analysis of the association between Apolipoprotein E polymorphism and risks of myocardial infarction.

ABSTRACT:

Background

Myocardial infarction (MI) remains the leading cause of death and disability among cardiovascular diseases worldwide. Studies show that elevated low-density lipid protein cholesterol (LDL-C) levels confer the highest absolute risk of MI, and Apolipoprotein E (ApoE) is implicated in regulating levels of triglycerides (TGs), cholesterol, and LDL-C. Our study aimed to evaluate the association between APOE polymorphism and MI, and to provide evidence for the etiology of MI.

Methods

Case-control studies on the association between APOE polymorphisms and the risk of myocardial infarction were included by searching PubMed, Web of Science, and CNKI, and this meta-analysis was written in accordance with PRISMA guideline statement. Odds ratios (ORs) and 95% confidence interv

SUBMITTER: Shao A 

PROVIDER: S-EPMC8952226 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature