High Resolution Magic Angle Spinning Proton NMR Study of Alzheimer's Disease with Mouse Models.

ABSTRACT: Alzheimer's disease (AD) is a crippling condition that affects millions of elderly adults each year, yet there remains a serious need for improved methods of diagnosis. Metabolomic analysis has been proposed as a potential methodology to better investigate and understand the progression of this disease; however, studies of human brain tissue metabolomics are challenging, due to sample limitations and ethical considerations. Comprehensive comparisons of imaging measurements in animal models to identify similarities and differences between aging- and AD-associated metabolic changes should thus be tested and validated for future human non-invasive studies. In this paper, we present the results of our highresolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) studies of AD an

SUBMITTER: Fuzesi MV 

PROVIDER: S-EPMC8952313 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature