Efficacy and safety of botulinum toxin type A in distraction osteogenesis of the lower extremities: a meta-analysis of randomized controlled trials.

ABSTRACT:

Background

To explore the efficacy and safety of botulinum toxin in patients who received distraction osteogenesis of the lower extremities.

Methods

We searched the PubMed, Medline, Cochrane Library, and Web of Science databases for randomized controlled trials that administered botulinum toxin to individuals who underwent distraction osteogenesis of the lower limbs. The final search was conducted on July 6, 2021. Quality assessments were conducted using the Cochrane risk of bias tool and the Jadad scale. We performed random-effects meta-analysis to calculate the standardized mean differences (SMDs) and confidence intervals (CIs) of the pooled effect sizes, and subgroup analysis and meta-regression were performed for potential moderators.

Results

Our analysis of four

SUBMITTER: Su YC 

PROVIDER: S-EPMC8953065 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature