The Effect of Lithium on the Budding Yeast Saccharomyces cerevisiae upon Stress Adaptation.

ABSTRACT: Lithium salts are used in the treatment of mood disorders, cancer, and Alzheimer's disease. It has been shown to prolong life span in several phyla; however, not yet in budding yeast. In our study, we investigate the influence of lithium on yeast cells' viability by characterizing protein aggregate formation, cell volume, and molecular crowding in the context of stress adaptation. While our data suggest a concentration-dependent growth inhibition caused by LiCl, we show an extended long-term survival rate as an effect of lithium addition upon glucose deprivation. We show that caloric restriction mitigates the negative impact of LiCl on cellular survival. Therefore, we suggest that lithium could affect glucose metabolism upon caloric restriction, which could explain the extended long-term s

SUBMITTER: Reith P 

PROVIDER: S-EPMC8953283 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature