Central role of c-Src in NOX5- mediated redox signalling in vascular smooth muscle cells in human hypertension.

ABSTRACT:

Aims

NOX-derived reactive oxygen species (ROS) are mediators of signalling pathways implicated in vascular smooth muscle cell (VSMC) dysfunction in hypertension. Among the numerous redox-sensitive kinases important in VSMC regulation is c-Src. However, mechanisms linking NOX/ROS to c-Src are unclear, especially in the context of oxidative stress in hypertension. Here, we investigated the role of NOX-induced oxidative stress in VSMCs in human hypertension focusing on NOX5, and explored c-Src, as a putative intermediate connecting NOX5-ROS to downstream effector targets underlying VSMC dysfunction.

Methods and results

VSMC from arteries from normotensive (NT) and hypertensive (HT) subjects were studied. NOX1,2,4,5 expression, ROS generation, oxidation/phosphorylation of signal

SUBMITTER: Camargo LL 

PROVIDER: S-EPMC8953456 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature