Role of Extracellular High-Mobility Group Box-1 as a Therapeutic Target of Gastric Cancer.

ABSTRACT:

Background

High-mobility group box-1 (HMGB1) is involved in the tumorigenesis and metastasis of various cancers. The present study investigated the roles of extracellular HMGB1 in the progression of gastric cancer (GC) and the therapeutic effects of recombinant human soluble thrombomodulin (rTM) targeting HMGB1.

Methods

The effects of extracellular HMGB1 and rTM on GC cells were assessed using proliferation and Transwell assays. Their effects on local tumor growth and metastasis were evaluated using subcutaneous tumor and liver metastasis mouse models, respectively. Plasma HMGB1 concentrations in GC patients were measured using ELISA. The relationships between plasma HMGB1 concentrations and the prognosis and clinicopathological factors of patients were also investigated.

SUBMITTER: Takaki W 

PROVIDER: S-EPMC8953630 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature