LRP1 loss in airway epithelium exacerbates smoke-induced oxidative damage and airway remodeling.

ABSTRACT: The LDL receptor-related protein 1 (LRP1) partakes in metabolic and signaling events regulated in a tissue-specific manner. The function of LRP1 in airways has not been studied. We aimed to study the function of LRP1 in smoke-induced disease. We found that bronchial epithelium of patients with chronic obstructive pulmonary disease and airway epithelium of mice exposed to smoke had increased LRP1 expression. We then knocked out LRP1 in human bronchial epithelial cells in vitro and in airway epithelial club cells in mice. In vitro, LRP1 knockdown decreased cell migration and increased transforming growth factor β activation. Tamoxifen-inducible airway-specific LRP1 knockout mice (club Lrp1^-/-) induced after complete lung development had increased inflammation in the bronchoalveola

SUBMITTER: Garcia-Arcos I 

PROVIDER: S-EPMC8953659 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature