Combination of FLG mutations and SNP of TSLP (rs1898671) influence on atopic dermatitis occurrence.

ABSTRACT:

Introduction

Atopic dermatitis (AD) is a common, chronic, relapsing and heterogeneous inflammatory skin disease. Its main causes are genetic predispositions, the epidermal barrier defect, and immune system dysfunction. Thymic stromal lymphopoietin (TSLP) is highly expressed in the epidermis of AD patients and its production is triggered by exposure to environmental factors, allergens, microorganisms and irritants.

Aim

To search for the associations between rs1898671 polymorphism in the promotor region of the TSLP gene (SNP) and AD occurrence and course.

Material and methods

The frequency of polymorphism occurrence was examined, connection with IgE level, the severity of AD, itching, and concomitant asthma occurrence and combination with FLG gene mutations (2282del4, R

SUBMITTER: Klonowska J 

PROVIDER: S-EPMC8953872 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature