Combination of FLG mutations and SNPs of IL-17A and IL-19 influence on atopic dermatitis occurrence.

ABSTRACT:

Introduction

Atopic dermatitis (AD) is a heterogeneous inflammatory skin disease. A fresh look on the AD pathophysiology has focused on the skin barrier defect and immune dysfunctions. IL-17A and IL-19 seem to play role in AD pathogenesis.

Aim

The aim was to investigate associations of SNPs of IL-17A (rs2275913) and IL-19 (rs22431188) with AD features, course and occurrence. Searching for prognostic panels composed of FLG (2282del4, R501X) mutations with IL-17A and IL-19 polymorphisms.

Material and methods

Blood samples were collected from 239 patients with AD and 170 controls. Two SNPs, IL-17A and IL-19 and FLG null mutations were analyzed. PCR and RFLP restriction fragment length polymorphism analysis were used. SCORAD score to establish AD severity, VAS to estimate

SUBMITTER: Klonowska J 

PROVIDER: S-EPMC8953886 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature