Cost-Effectiveness of Screening Algorithms for Familial Hypercholesterolaemia in Primary Care.

ABSTRACT: Although familial hypercholesterolemia (FH) screening within primary care is considered cost-effective, which screening approach is cost-effective has not been established. This study determines the cost-effectiveness of six case-finding strategies for screening of electronic health records to identify index patients who have genetically confirmed monogenic FH in English primary care. A decision tree was constructed to represent pathways of care for each approach (FH Case Identification Tool (FAMCAT) versions 1 and 2, cholesterol screening, Dutch Lipid Clinic Network (DLCN), Simon Broome criteria, no active screening). Clinical effectiveness was measured as the number of monogenic FH cases identified. Healthcare costs for each algorithm were evaluated from an NHS England perspective over a

SUBMITTER: Jones M 

PROVIDER: S-EPMC8953997 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature