Corepressors SsnF and RcoA Regulate Development and Aflatoxin B₁ Biosynthesis in Aspergillus flavus NRRL 3357.

ABSTRACT: Aspergillus flavus is a saprophytic fungus that can be found across the entire world. It can produce aflatoxin B₁ (AFB₁), which threatens human health. CreA, as the central factor in carbon catabolite repression (CCR), regulates carbon catabolism and AFB₁ biosynthesis in A. flavus. Additionally, SsnF-RcoA are recognized as the corepressors of CreA in CCR. In this study, ssnF and rcoA not only regulated the expressions of CCR factors and hydrolase genes, but also positively affected mycelia growth, conidia production, sclerotia formation, and osmotic stress response in A. flavus. More importantly, SsnF and RcoA were identified as positive regulators for AFB₁ biosynthesis, as they modulate the AF cluster genes and

SUBMITTER: Ma X 

PROVIDER: S-EPMC8954095 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature