Immunogenicity and Safety of Childhood Combination Vaccines: A Systematic Review and Meta-Analysis.

ABSTRACT: Vaccination is considered the most effective and economical measure for controlling infectious diseases. Although combination vaccines are widely used worldwide, whether any of the combination vaccines is superior to each separate vaccine has yet to be established. This systematic review and meta-analysis aimed to summarize the available evidence on the effectiveness and safety of combination vaccines in children. A systematic search was conducted from database inception to August 20, 2021, in MEDLINE, Embase, Cochrane, and Scopus. Published randomized clinical trials (RCTs) and open-label trials of immunogenicity and safety of combined vaccines were selected. The results of the studies were quantitatively synthesized. Overall, 25 articles met the inclusion criteria and were included in th

SUBMITTER: Liu B 

PROVIDER: S-EPMC8954135 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature