Understanding the Variability of Certain Biological Properties of H1N1pdm09 Influenza Viruses.

ABSTRACT: The influenza virus continually evolves because of the high mutation rate, resulting in dramatic changes in its pathogenicity and other biological properties. This study aimed to evaluate the evolution of certain essential properties, understand the connections between them, and find the molecular basis for the manifestation of these properties. To that end, 21 A(H1N1)pdm09 influenza viruses were tested for their pathogenicity and toxicity in a mouse model with a ts/non-ts phenotype manifestation and HA thermal stability. The results demonstrated that, for a strain to have high pathogenicity, it must express a toxic effect, have a non-ts phenotype, and have a thermally stable HA. The ancestor A/California/07/2009 (H1N1)pdm influenza virus expressed the non-ts phenotype

SUBMITTER: Al Farroukh M 

PROVIDER: S-EPMC8954537 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature