Transcriptomic Heterogeneity of Gleason Grade Group 5 Prostate Cancer.

ABSTRACT: Gleason grade group (GG) 5 prostate cancer has been associated with an aggressive natural history, and retrospective data support a role for treatment intensification. However, clinical outcomes remain heterogeneous in this cohort, and intensified treatments carry an increased risk of adverse events. We sought to explore the transcriptomic heterogeneity of GG 5 tumors by querying transcriptomic data from the tumors of 2138 patients with GG 5 disease who underwent prostatectomy. Four distinct consensus clusters were identified with respect to differential transcriptional activation of hallmark pathways, with distinct molecular subtyping profiles and different average genomic risks (AGRs). One cluster, accounting for 325 tumors (15.2% of the population), was enriched for genes related to the

SUBMITTER: Kishan AU 

PROVIDER: S-EPMC8954568 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature